Abstract Library

#1010 Soluble VCAM-1 and Its Relation to Clinical Staging and Histological Grading in Neuroendocrine Neoplasms (NENs)

Introduction: Cellular adhesion molecules play an important role in tumor progression and metastasis.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Rosiek V, Foltyn W, Strzelczyk J, Zemczak A, Kos-Kudła B,

Keywords: neuroendocrine neoplasms, sVCAM-1, histological grade, clinical stage,

#988 Vimentin and E-cadherin Expression in Primary Neuroendocrine Tumors by Grade

Introduction: The prognostic evaluation of radically removed neuroendocrine tumors (NETs) represents an important issue. The cardinal tumor features can be studied as biomarkers.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Vanags A, Strumfa I, Simtniece Z, Vasko E, Gardovskis J,

Keywords: NETs, vimentin, E-cadherin,

#894 The Effects of cAMP in Different Neuroendocrine Tumorous Cells: The Role of Epac and PKA in Cell Proliferation and Cell Adhesion

Introduction: cAMP is implicated in the inhibition or stimulation of proliferation depending on cell type. Although the effects exerted by cAMP were initially attributed to the PKA activation, two cAMP-activated guanine nucleotide exchange (Epac1/2) have been later identified as cAMP targets.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Vitali E, Zerbi A, Peverelli E, Mantovani G, Cambiaghi V,

Keywords: cAMP, PKA, EPAC, GEP-NET,

#110 Slug represents an important regulator of E-cadherin expression in neuroendocrine tumor cells of the pancreas

Introduction: Neuroendocrine tumors of the pancreas form an inhomogenous group of epithelial neoplasms. They differ from other types of pancreatic cancers by showing an extended survival of patients, which is due to a mostly slow proliferation rate of the tumor. However, some of these neuroendocrine tumors are characterized by an early onset of metastases, which cannot be predicted by any available method. The epithelial to mesenchymal transition (EMT) represents a central part of cell migration and metastasis. During EMT, cells loosen their cellular contacts, leave the tissue, and become migrating single cells. One of the integral compounds of cell adhesion represents the E-cadherin adhesion module, which contains mostly E-cadherin and several catenins. A loss of this adhesion module is associated with tumor progression, migration and metastasis in many types of cancer.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author: König A

Authors: König A, Reutlinger K, Ellenrieder V, Gress T, Fendrich V,

Keywords: neuroendocrine tumor of the pancreas, E-cadherin, Slug, cell adhesion,

#87 Alterations of E-cadherin, beta-catenin and caveolin-1 expression in gastroenteropancreatic neuroendocrine tumors

Introduction: Gastroenteropancreatic neuroendocrine tumors (GEP NETs) comprise a heterogeneous group of neoplasm with different histological patterns and biological behavior. Only limited information is available on immunohistochemical prognostic factors of disease. Alterations in the cell-cell adhesion system are closely associated with cell invasion and metastasis in many malignancies, including those of endocrine origin. Abnormal expression of E-cadherin and beta-catenin has been reported to play an important role in these processes. Caveolin-1 has recently been identified as a tumor metastasis modifier factor, which might increase the cell metastasis potential through the interaction with E-cadherin. However, the role of caveolin-1 in GEP NETs cell invasion remains unknown.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author:

Authors: Delektorskaya V, Chemeris G,

Keywords: immunohistochemistry, E-cadherin, beta-catenin, caveolin-1, cyclin D1, Ki67, gastroenteropancreatic neuroendocrine tumors, metastasis,